RESUMO
BACKGROUND AND STUDY AIMS: Celiac disease (CD) management is based on a lifelong gluten-free diet (GFD) that affects the quality of life (QoL) of patients with CD. Specific instruments have been used to evaluate this QoL, such as the CD-Questionnaire (CD-Q). This study aimed to translate, validate, and cross-culturally adapt the CD-Q in an Arabic version and then apply it to evaluate the QoL of Moroccan adult patients with CD. PATIENTS AND METHODS: The Moroccan version of the CD-Q (M-CD-Q) was administered to 150 patients with CD, and 112 of them completed it. The reproducibility and reliability of the M-CD-Q were studied by the intraclass coefficient (ICC) and Cronbach's α, respectively. Parametric and nonparametric tests, confirmatory factor analysis, and Spearman correlation were used for the statistical analysis performed by SPSS, and the goodness-of-fit test was determined using SPSS AMOS. RESULTS: No difficulties were found during the translation and cultural adaptation of the CD-Q. Cronbach's α showed good internal consistency. The retest showed excellent reproducibility (ICC > 0.4). The study of the psychometric properties of the M-CD-Q showed good acceptance, zero ceiling effect, and floor effect. The model fit was good [(root mean square error of approximation = 0.075 (<0.08) and χ2 = 509.04, p < 0.001]. The total scores showed a neutral QoL. This QoL was worse in the worries subscale, which is related to gluten-free products. The GFD did not improve the QoL of the examined samples. CONCLUSION: The M-CD-Q is the first reliable and adapted instrument in an Arab country for the evaluation of QoL in patients with CD. CD negatively influences this QoL, especially items related to gluten-free products.
Assuntos
Doença Celíaca , Qualidade de Vida , Humanos , Reprodutibilidade dos Testes , Doença Celíaca/diagnóstico , Comparação Transcultural , Projetos de PesquisaRESUMO
Malignant melanoma is a disease with high metastatic potential which starts in melanocytes. The liver is the organ most often targeted for metastatic spread. Nonetheless, primary liver melanoma is very rare. Few cases have been described. We here report the case of a female patient with primary liver melanoma diagnosed based on liver biopsy results and confirmed by histological and immunohistochemical analyses as well as by providing a comprehensive assessment excluding other localizations.
Assuntos
Neoplasias Hepáticas/diagnóstico , Melanoma/diagnóstico , Biópsia , Feminino , Humanos , Neoplasias Hepáticas/patologia , Melanoma/patologia , Pessoa de Meia-IdadeRESUMO
Testicular germ cell tumors are the most common cancers in young men. In most cases, patients may present a painless testicular swelling. However, in 10% the presentation is variable and related to site of metastasis and complications. Clinically apparent gastrointestinal involvement was seen in 5% of cases and dominates by gastrointestinal bleeding. We report a case of testicular choriocarcinoma involving the small intestine revealed by melena and complicated by acute intussusception.
Assuntos
Coriocarcinoma/diagnóstico , Neoplasias Intestinais/diagnóstico , Neoplasias Embrionárias de Células Germinativas/diagnóstico , Neoplasias Testiculares/diagnóstico , Adulto , Coriocarcinoma/patologia , Hemorragia Gastrointestinal/etiologia , Humanos , Neoplasias Intestinais/secundário , Intestino Delgado/patologia , Intussuscepção/etiologia , Masculino , Neoplasias Embrionárias de Células Germinativas/patologia , Neoplasias Testiculares/patologiaRESUMO
Splenic tuberculosis and Pott´s disease are two rare entities, in particular in immunocompetent people. We here report the case of a 57-year-old immunocompetent woman presenting with atypical pain in the left hypochondriac region evolving over the last 3 months, associated with lower limb paraparesis with progressive onset. Laboratory data did not provide any specific information regarding diagnosis, except for positive response to the QuantiFERON Test. Abdominal and pelvic computed tomography (CT) scan showed splenomegaly with multiple nodular, hypodense lesions in the spleen. Spinal cord magnetic resonance imaging (MRI) showed spondyldiscitis at the D10/D11 level with epidural and paravertebral collections responsible for medullary compression. GeneXpert assay on bone biopsy was positive and histological examination objectified granuloma characterized by the presence of central caseous necrosis. The diagnosis of multifocal tuberculosis was retained.
Assuntos
Tuberculose da Coluna Vertebral , Tuberculose Esplênica , Feminino , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Esplenomegalia/etiologia , Tuberculose da Coluna Vertebral/diagnóstico , Tuberculose Esplênica/diagnósticoRESUMO
INTRODUCTION: coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 was first reported in Wuhan, China. Clinical spectrum of this disease has nonspecific symptoms shared by many other frequent infectious diseases of the respiratory tract and other respiratory tract diseases. This study explains the importance of differential diagnosis between COVID-19 and other lung diseases. METHODS: we analyzed in this study, the demographic features, clinical presentations, laboratory data and radiologic findings of the COVID-19 patients in comparison to those with other respiratory infections or diseases. RESULTS: the mean age of all patients was 38.04 years; 35 patients were later confirmed to be positive for SARS-CoV-2 infection. The most common symptoms reported by both groups included nonproductive cough and myalgia. Two of the non-COVID-19 patients were having below 92% oxygen saturation and low systolic blood pressure. The patients shared relatively similar laboratory findings except 3% of the non-COVID-19 patients who had lympho-neutropenia and 22.6% had high levels of C-reactive protein. Pulmonary tuberculosis and autoimmune disease respiratory disorder were suspected in 2 of the non-COVID-19 patients respectively. CONCLUSION: we emphasize the importance of good screening protocols, rapid detection of SARS-CoV-2 and other most common respiratory pathogens, which may help for a better control of COVID-19 spread and avoid delayed care of other lung diseases.
Assuntos
Betacoronavirus , Técnicas de Laboratório Clínico , Infecções por Coronavirus/diagnóstico , Pneumonia Viral/diagnóstico , Avaliação de Sintomas/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Betacoronavirus/isolamento & purificação , COVID-19 , Teste para COVID-19 , Infecções por Coronavirus/epidemiologia , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Marrocos/epidemiologia , Oxigênio/sangue , Pandemias , Pneumonia Viral/epidemiologia , Doenças Respiratórias/diagnóstico , SARS-CoV-2 , Adulto JovemRESUMO
Coeliac disease is an autoimmune enteropathy related to gluten intolerance which occurs in subjects genetically disposed. The diagnosis is based on the combination of clinical biological and histological arguments. It is associated with many complications, including lymphoma. The risk of tuberculosis in patients with coeliac disease is increased. Several hypotheses explaining this association have been discussed. We report a case of coeliac disease associated with multifocal tuberculosis in a 17-year old patient.
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Doença Celíaca/etiologia , Tuberculose/complicações , Adolescente , Feminino , Humanos , RiscoAssuntos
Antivirais/uso terapêutico , Hepatite C Crônica/tratamento farmacológico , Diálise Renal , Insuficiência Renal Crônica/terapia , Adulto , Fatores Etários , Idoso , Antivirais/efeitos adversos , Feminino , Humanos , Cirrose Hepática/patologia , Masculino , Pessoa de Meia-Idade , Marrocos , Análise Multivariada , Estudos Retrospectivos , Resultado do Tratamento , Carga Viral , Adulto JovemAssuntos
Equinococose Hepática/diagnóstico , Varizes Esofágicas e Gástricas/etiologia , Hemorragia Gastrointestinal/etiologia , Hipertensão Portal/etiologia , Adulto , Albendazol/uso terapêutico , Anemia Ferropriva/etiologia , Anti-Helmínticos/uso terapêutico , Terapia Combinada , Equinococose Hepática/complicações , Equinococose Hepática/diagnóstico por imagem , Equinococose Hepática/tratamento farmacológico , Equinococose Hepática/cirurgia , Hematemese/etiologia , Hepatectomia/métodos , Humanos , Masculino , Tomografia Computadorizada por Raios XAssuntos
Glicemia/metabolismo , Tumores do Estroma Gastrointestinal/complicações , Hipoglicemia/etiologia , Fator de Crescimento Insulin-Like II/metabolismo , Síndromes Endócrinas Paraneoplásicas , Biópsia , Diagnóstico Diferencial , Evolução Fatal , Feminino , Tumores do Estroma Gastrointestinal/diagnóstico , Tumores do Estroma Gastrointestinal/metabolismo , Humanos , Hipoglicemia/diagnóstico , Hipoglicemia/metabolismo , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios XRESUMO
Primary mucinous adenocarcinoma is a rare malignancy of the anus (3% of anal cancers), the pathogenesis of which is better understood by immunohistochemistry. We reviewed cases of primary mucinous adenocarcinoma of the anus from 2000 to 2009 in the Hepatogastroenterology Department of the University Hospital Centre of Marrakech. Three cases were identified who were males with the mean age of 68years, and presented with a chronic anal fistula. Two cases had anal pain. Clinical examination revealed multiple fistulae in two cases with a secretion simulating 'cooked grains of tapioca'. Diagnosis was confirmed by histopathology and immunohistochemical profile (CK7 positive/CK20 negative). Imaging revealed a retro-rectal collection with thickening of the anal wall without metastasis (two cases). One patient underwent abdominoperinal resection without recurrence.